rnpB [2019-08-30 17:34:21]

RNA component of RNase P

locus: BSU_misc_RNA_35

pI: 0.00

mw: 0.00 kDa

function: cleavage of precursor sequences from the 5 ends of pre-tRNAs

product: RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)

essential: yes

synonyms: rnaP

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.4|RNases] → [category|SW 3.2.4.4|RNases/ Other]
• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
• [category|SW 6|Groups of genes] → [category|SW 6.9|NcRNA] → [category|SW 6.9.4|RNA component of RNase P]

Gene

Phenotypes of a mutant

• essential [Pubmed|23109554]

RNA

Structure

• [PDB|3Q1R] (complex of [protein|594F2D36BE71A45303A33AA2A2931F56F0A969ED|RnpA] with [protein|57A79AAF00243B5E058FA901D43AA7B55CA33F63|RnpB] and [gene|3B6620F44EC08BA9B02FE9359A5F74C6CAE6D4FB|trnA-Ile], from ''Thermotoga maritima'') [Pubmed|21076397]

Expression and Regulation

Operons

• genes: [gene|C22F7704DC9D36D96FE089ADCEA546D7A3FB3739|gpsB]-[gene|57A79AAF00243B5E058FA901D43AA7B55CA33F63|rnpB]-[gene|0DF27BEAF763545258CE7DD56F65CD5BF74DD887|ypsC]
  description: [Pubmed|22383849]

• genes: [gene|57A79AAF00243B5E058FA901D43AA7B55CA33F63|rnpB]-[gene|0DF27BEAF763545258CE7DD56F65CD5BF74DD887|ypsC]
  description: [Pubmed|22383849]

labs

• [SW|Carol Fierke], University of Michigan, Ann Arbor, USA [https://www.chem.lsa.umich.edu/chem/faculty/facultyDetail.php?Uniqname=fierke homepage]
• [SW|Roland Hartmann], Marburg University, Germany [http://www.pharmazie.uni-marburg.de/pharmchem/akhartmann/ag_hartmann.htm homepage]

References

Reviews

• 19215776,17868095,14691942,16650980,16980936,16679018,14550630

Original Publications

• 16470227,17355991,11812129,10390342,11454206,19549719,11454206,19717440,20133747,19932118,20188108,20434461,17299131,14510496,25402410,12951523,12836338,11577704,20557101,25352137,23109554,21076397,21622899,29116782,21076397,31003868